Lenacapavir binding to immature Gag induces giant virions and causes protease-dependent inhibition of viral release

Amesimeku WAO, Nakata Y, Monde N, Terasawa H, Ode H, Sasaki H, Nishimura S, Matsui T, Nyame P, Hossain MJ, Takahashi M, Ikeda T, Saito A, Sawa T, Maeda Y, Iwatani Y*, Monde K* (equal correspondence). Lenacapavir binding to immature Gag induces giant virions and causes protease-dependent inhibition of viral release. Proc Natl Acad Sci U S A, 123, e2609634123, 2026.